Vascular Endothelial Growth Factor A Receptor 2 (VEGFR2)

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), also known as KDR, is a type IV receptor tyrosine kinase that plays a crucial role in angiogenesis. It is primarily expressed on vascular endothelial cells and is a major mediator of angiogenesis by regulating endothelial cell proliferation, migration, survival, and permeability. VEGFR2 is activated by ligands such as VEGFA, VEGFC, VEGFD, and VEGF-E, leading to dimerization and autophosphorylation, which in turn activates downstream signaling pathways. Due to its central role in pathological angiogenesis, it is a major target for anti-cancer therapies aiming to inhibit tumor blood supply.

Other names

KDRKinase Insert Domain ReceptorCD309Flk-1Fetal Liver Kinase 1

Inhibition of KDR/VEGFR2 activity or its interaction with ligands like VEGFA/E using antibodies or small molecule inhibitors.