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Target intelligence / Profile preview
Vascular Endothelial Growth Factor A165 (None)
- Target
- None
- Molecular classification
- Growth Factor, PDGF/VEGF Family, Cytokine
01
Overview
Vascular endothelial growth factor A165 (VEGF-A165) is a major isoform of VEGF-A, a key signaling protein involved in both physiological and pathological angiogenesis. It stimulates proliferation, migration, and survival of vascular endothelial cells and induces angiogenesis. VEGF-A165 acts primarily through binding to its main receptors: VEGFR1 (FLT1) and VEGFR2 (KDR/Flk1), and also binds neuropilin-1 receptor (NRP1). It is a therapeutic target in cancer, with several anti-cancer therapies designed to inhibit its function.
- Other names
- VEGF-A165VEGF(165)VEGF165
02
Mechanism of action
Inhibition of VEGF-A165 binding to VEGFR1 and/or VEGFR2, preventing downstream signaling and angiogenesis.
03
Biological functions
AngiogenesisVasculogenesisEndothelial cell proliferationEndothelial cell migrationEndothelial cell survivalIncreased vascular permeabilityCell migrationInhibition of apoptosis
04
Disease associations
CancerPOEMS syndrome/Crow-Fukase syndromeMicrovascular complications of diabetes mellitus type IAtherosclerosis
05
Safety considerations
HypertensionProteinuriaThrombotic eventsImpaired wound healing
06
Interacting drugs
Monoclonal antibodies against VEGF-A
2 more in the full profile.
07
Biomarkers
VEGF-A165 levels in tumor tissueVEGF-A165 levels in plasma
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