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Target intelligence / Profile preview
Vascular endothelial growth factor B receptor 1 (VEGFR1)
- Target
- VEGFR1
- Molecular classification
- Receptor, Receptor tyrosine kinase
01
Overview
Vascular endothelial growth factor receptor 1 (VEGFR1), also known as FLT1, is a receptor tyrosine kinase that plays a crucial role in angiogenesis and vasculogenesis. It binds VEGF-A, VEGF-B, and PlGF, modulating endothelial cell function, monocyte migration, and differentiation. The receptor exists in full-length and soluble forms. sFlt-1 overexpression is implicated in preeclampsia. FLT1 is also involved in cancer progression and inflammatory diseases.
- Other names
- FLT1Flt-1VEGFR-I
02
Mechanism of action
Not applicable, this is a target description
03
Biological functions
Angiogenesis regulationVasculogenesisSignal transductionCell proliferationMonocyte migrationMonocyte differentiation
04
Disease associations
CancerPreeclampsiaInflammatory Diseases
05
Safety considerations
Potential for hypertension through sFlt-1 overexpressionConcerns related to affecting angiogenesis in normal tissue
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