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Target intelligence / Profile preview
Vascular Endothelial Growth Factor D (VEGF-D)
- Target
- VEGF-D
- Molecular classification
- Growth Factor, PDGF/VEGF family, Secreted Glycoprotein
01
Overview
Vascular Endothelial Growth Factor D (VEGF-D) is a secreted glycoprotein and a member of the PDGF/VEGF family. It plays a crucial role in angiogenesis, lymphangiogenesis, and endothelial cell growth. VEGF-D undergoes proteolytic maturation and binds to VEGFR-2 and VEGFR-3 receptors. It is implicated in tumor metastasis and cardiovascular disease, making it a potential therapeutic target.
- Other names
- FIGFC-fos-induced growth factor
02
Mechanism of action
VEGF-D binds and activates VEGFR-2 and VEGFR-3 receptors, initiating downstream signaling cascades that promote angiogenesis and lymphangiogenesis.
03
Biological functions
AngiogenesisLymphangiogenesisEndothelial cell proliferationEndothelial cell migrationEndothelial cell survivalBlood vessel developmentLymphatic system remodelingTissue repair
04
Disease associations
CancerCardiovascular DiseaseTumor metastasisEpithelial ovarian carcinoma
05
Safety considerations
Potential for off-target effects on normal blood vessel and lymphatic vessel development.Unintended promotion of angiogenesis in non-cancerous tissues.
06
Biomarkers
VEGF-D expression levels in tumorsRegional lymph node metastasis
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