Vascular Endothelial Growth Factor Expression Pathway

The vascular endothelial growth factor (VEGF) expression pathway is a critical signaling cascade that regulates the formation of new blood vessels (angiogenesis), vascular permeability, and various cellular processes such as proliferation, migration, and survival. VEGF is a signal protein produced by many cell types and acts primarily on endothelial cells via specific tyrosine kinase receptors. Overexpression contributes to diseases such as cancer progression/metastasis and retinal vascular diseases. Blockade of this pathway forms a major therapeutic strategy in oncology and ophthalmology due to its central role in pathological neovascularization.

Inhibition of VEGF signaling