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Target intelligence / Profile preview
Vascular Endothelial Growth Factor Production
- Molecular classification
- Growth Factor, Cytokine, Signaling Pathway
01
Overview
Vascular endothelial growth factor (VEGF) production refers to the complex process of cells synthesizing and secreting VEGF proteins, key regulators of angiogenesis. This process is influenced by factors like hypoxia, growth factors, oncogenes, and tumor suppressors, and its dysregulation contributes to diseases characterized by abnormal blood vessel growth or permeability, such as cancer and diabetic retinopathy.
02
Mechanism of action
Regulation of angiogenesis and vascular permeability through tyrosine kinase receptor signaling.
03
Biological functions
AngiogenesisVasculogenesisVascular permeabilityEndothelial cell proliferationEndothelial cell migrationCell survivalHematopoiesisTissue regeneration
04
Disease associations
CancerDiabetic retinopathyMacular degenerationPOEMS syndromeCrow-Fukase syndrome
05
Safety considerations
Impaired tissue repair/regeneration with excessive inhibition
06
Interacting drugs
Antiangiogenic therapies (e.g., VEGF inhibitors)
07
Biomarkers
VEGF-A levels in serum/tissue
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