Vascular endothelial growth factor receptor 1, 2, 3 (VEGFRs)

Vascular endothelial growth factor receptor 1, 2, and 3 refer to a family of three distinct, but structurally and functionally related, receptor tyrosine kinases. While each receptor has unique primary roles (e.g., VEGFR1 in decoy signaling and monocyte chemotaxis, VEGFR2 in angiogenesis, VEGFR3 in lymphangiogenesis), they collectively mediate various aspects of vascular and lymphatic development, maintenance, and pathological processes. This entry is considered 'incorrect' for structured extraction as these are individually targetable proteins that should be treated separately for accurate annotation and data integrity.

Other names

VEGF receptor familyVEGF receptors

Drugs targeting these receptors primarily act through inhibition of VEGF-ligand binding, thereby preventing receptor activation, or by directly inhibiting the receptor's intrinsic tyrosine kinase activity, and in some cases, by sequestering ligands.