Vascular endothelial growth factor receptor family (VEGFR) (VEGFR)

The Vascular endothelial growth factor receptor (VEGFR) family consists of three primary receptor tyrosine kinases—VEGFR-1 (FLT1), VEGFR-2 (KDR), and VEGFR-3 (FLT4)—that are central regulators of angiogenesis, vasculogenesis, and lymphangiogenesis (UniProt: P17948, P35968, P35916). These receptors are activated by the binding of specific VEGF ligands, which induces receptor dimerization and aut}

Other names

VEGF receptorsFlt familyTyrosine-protein kinase receptor VEGFRFLT1/KDR/FLT4Vascular endothelial growth factor receptors

Inhibition of receptor tyrosine kinase activity or blocking ligand-receptor binding to suppress pro-angiogenic and pro-lymphangiogenic signaling pathways.