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Target intelligence / Profile preview
Vascular Endothelial Growth Factor Receptors 1-3 (VEGFR1-3)
- Target
- VEGFR1-3
- Molecular classification
- Receptor, Tyrosine kinase receptor
01
Overview
Vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR1, VEGFR2, VEGFR3) are a family of receptor tyrosine kinases that play central roles in the regulation of angiogenesis (formation of blood vessels), lymphangiogenesis (formation of lymphatic vessels), and vascular permeability. These receptors are activated by members of the VEGF ligand family and are key targets in cancer therapy due to their involvement in tumor vascularization.
- Other names
- VEGFR-1VEGFR-2VEGFR-3Flt-1KDRFlk-1Flt-4
02
Mechanism of action
Inhibition of VEGFR tyrosine kinase activity, blockade of ligand binding, or receptor downregulation to suppress angiogenesis and lymphangiogenesis.
03
Biological functions
AngiogenesisLymphangiogenesisVascular permeabilityEndothelial cell proliferationEndothelial cell migrationEndothelial cell survivalTube formationSignal transduction
04
Disease associations
CancerTumor progressionTumor metastasisChronic inflammatory diseasesOcular neovascular disorders
05
Safety considerations
Resistance to anti-angiogenic therapiesSide effects associated with kinase inhibitorsPotential for off-target effects
06
Interacting drugs
Anti-VEGF-A monoclonal antibodies
1 more in the full profile.
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