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Target intelligence / Profile preview
Vascular Endothelial Growth Factor Secretion (None)
- Target
- None
- Molecular classification
- Secreted protein, Growth factor
01
Overview
Vascular endothelial growth factor (VEGF) secretion refers to the process by which cells release VEGF, a heparin-binding glycoprotein that plays a central role in angiogenesis (the formation of new blood vessels), vasculogenesis, and vascular permeability. VEGF secretion is tightly regulated by factors such as hypoxia, cytokines, growth factors, oncogenes, and tumor suppressors, and its dysregulation is implicated in various diseases, particularly cancer.
02
Mechanism of action
VEGF secretion itself is not a mechanism of action but rather a process. Drugs target the VEGF molecule or its receptors.
03
Biological functions
Angiogenesis inductionIncreased vascular permeabilityCell migrationApoptosis modulationVasodilation
04
Disease associations
CancerIschemic diseasesInflammation
05
Safety considerations
Over-inhibition of angiogenesis can lead to impaired wound healingHypertensionThromboembolic events
06
Interacting drugs
Anti-VEGF therapies (e.g., Bevacizumab)
07
Biomarkers
VEGF levels in serum or tumor tissue
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