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Target intelligence / Profile preview
Vascular Endothelial Growth Inhibitor (VEGI)
- Target
- VEGI
- Molecular classification
- Cytokine, TNF superfamily ligand
01
Overview
Vascular Endothelial Growth Inhibitor (VEGI), also known as TNFSF15 or TL1A, is a cytokine that belongs to the TNF superfamily. It functions as an anti-angiogenic factor by inhibiting the proliferation of endothelial cells and suppressing angiogenesis. VEGI plays a role in modulating immune responses and vascular development, and it has been implicated in the pathogenesis of inflammatory diseases. As a cytokine, there is potential for immune-related adverse events.
- Other names
- TNFSF15TL1A
02
Mechanism of action
Inhibits endothelial cell proliferation and angiogenesis through interactions with its receptor.
03
Biological functions
Inhibition of angiogenesisSuppression of endothelial cell proliferationModulation of immune responsesRegulation of vascular development
04
Disease associations
Inflammatory diseasesCancerAutoimmune disorders
05
Safety considerations
Potential for immune-related adverse events due to cytokine activity.
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