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Target intelligence / Profile preview
Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP)
- Target
- VE-PTP
- Molecular classification
- Receptor-type protein tyrosine phosphatase, Transmembrane receptor
01
Overview
Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP) is a receptor-type protein tyrosine phosphatase predominantly expressed in vascular endothelial cells. It plays a crucial role in regulating angiogenesis, vascular permeability, and the integrity of endothelial cell junctions. VE-PTP acts by dephosphorylating key substrates like VE-cadherin and Tie2, influencing cell adhesion, signaling pathways, and vascular remodeling. Dysregulation of VE-PTP is implicated in various diseases, including cancer and inflammatory conditions, making it a potential therapeutic target for modulating angiogenesis and vascular function.
- Other names
- PTPRBProtein Tyrosine Phosphatase, Receptor Type B
02
Mechanism of action
Dephosphorylates tyrosine residues on target proteins, such as VE-cadherin and Tie2, to regulate their activity and downstream signaling pathways.
03
Biological functions
Angiogenesis regulationVascular developmentVascular homeostasisRegulation of endothelial junctionsCell adhesionVascular permeability regulation
04
Disease associations
CancerInflammationVascular permeability disordersTumor angiogenesisVasculogenic mimicry
05
Safety considerations
Modulating VE-PTP activity can have complex effects on vascular stability and permeability, requiring careful titration to avoid adverse effects.Potential for off-target effects due to the broad substrate specificity of phosphatases.Disrupting normal angiogenesis during development may cause embryonic lethality.
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