Vascular Shutdown

Vascular shutdown refers to the process of blocking or reducing blood flow through blood vessels, often used in therapeutic contexts to inhibit tumor growth by depriving cancer cells of oxygen and nutrients. It can be achieved through various methods, including ultrasound therapy with microbubbles, photodynamic therapy, and radiation therapy. This process is not a specific molecular target but rather a therapeutic strategy involving multiple biological pathways and mechanisms.

Other names

Vascular OcclusionBlood Vessel Shutdown

Involves damage to endothelial cells, leading to platelet aggregation and clotting, often through mechanisms like cavitation in ultrasound therapy or activation of specific pathways in photodynamic therapy.