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Target intelligence / Profile preview
Vascular Smooth Muscle Cell Calcium Channel
- Molecular classification
- Ion channel, Voltage-gated calcium channel, CaV1 family channel
01
Overview
Vascular smooth muscle cell calcium channels, primarily the L-type voltage-gated CaV1.2 channel, are critical for regulating vascular tone, contractility, and intracellular calcium signaling in vascular smooth muscle cells. These channels mediate calcium influx upon membrane depolarization, leading to vasoconstriction and influencing blood pressure. Dysregulation of these channels contributes to various cardiovascular diseases, including hypertension and atherosclerosis, making them important therapeutic targets for antihypertensive drugs.
- Other names
- VSMC Calcium ChannelL-type Calcium Channel (CaV1.2)CaV1.2 ChannelVoltage-gated Calcium Channel in VSMC
02
Mechanism of action
L-type calcium channel blockers inhibit calcium influx through CaV1.2 channels in vascular smooth muscle cells, leading to vasodilation and reduced blood pressure.
03
Biological functions
Regulation of vascular toneVasoconstrictionVasodilationIntracellular calcium signalingGene expression regulationCell proliferationCell migrationExcitation-contraction couplingMyogenic response
04
Disease associations
HypertensionAtherosclerosisDiabetes-related vasculopathyArteriosclerosisVascular calcificationCardiovascular disease
05
Safety considerations
HypotensionEdemaReflex tachycardia
06
Interacting drugs
Amlodipine
2 more in the full profile.
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