Vascular Smooth Muscle Cell Contraction (VSMC Contraction)

Vascular smooth muscle cell contraction is the process by which the diameter of blood vessels is regulated, controlling blood flow and pressure. This process involves multiple signaling pathways, including calcium-dependent and calcium-independent mechanisms, which converge on the phosphorylation and dephosphorylation of myosin light chains to regulate actin-myosin crossbridge cycling. Dysregulation of VSMC contraction contributes to diseases such as hypertension and shock.

Other names

Vascular Tone RegulationSmooth Muscle Contraction (Vascular)Vasoconstriction/Vasodilation

Varies depending on the specific drug. Examples include blocking calcium influx, inhibiting Rho kinase, blocking adrenergic receptors, blocking angiotensin receptors, or increasing nitric oxide production. All alter the balance of contractile/relaxant forces.