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Target intelligence / Profile preview
Vascular Smooth Muscle Cell Contraction Pathway (VSMC Contraction Pathway)
- Target
- VSMC Contraction Pathway
- Molecular classification
- Signaling Pathway
01
Overview
The vascular smooth muscle cell (VSMC) contraction pathway is a critical signaling cascade that regulates the contractile state of blood vessels, thereby controlling vascular tone, blood flow, and blood pressure. It involves calcium-dependent and calcium-independent mechanisms, primarily through MLCK and RhoA/ROCK signaling. Dysregulation contributes to hypertension and other cardiovascular diseases.
- Other names
- Vascular Tone RegulationSmooth Muscle ContractionVSMC Contraction
02
Mechanism of action
N/A
03
Biological functions
Regulation of vascular toneControl of blood flowRegulation of blood pressureVasoconstrictionVasodilation
04
Disease associations
HypertensionCardiovascular diseaseVasospasmAtherosclerosisPulmonary HypertensionErectile Dysfunction
05
Safety considerations
Excessive vasoconstriction leading to ischemiaDysregulation leading to hypertensionSide effects of drugs targeting pathway components (e.g., hypotension with calcium channel blockers)
06
Interacting drugs
Calcium channel blockers
7 more in the full profile.
07
Biomarkers
N/A
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