Vascular smooth muscle cell protein

"Vascular smooth muscle cell proteins" is a broad, non-specific category rather than a canonical molecular target or single protein. Vascular smooth muscle cells (VSMCs) are contractile cells found in the walls of blood vessels, responsible for regulating vessel tone and blood pressure. These cells express a diverse set of contractile and structural proteins, including smooth muscle actin (ACTA2), myosin heavy chain 11 (MYH11), SM22α (Tagln), calponin, and smoothelin, among others[1][3][4]. VSMCs are known for remarkable phenotypic plasticity, transitioning between contractile and synthetic states, and contributing to vascular diseases like atherosclerosis and aneurysm via processes such as proliferation, migration, differentiation, apoptosis, and extracellular matrix production[1][3][5][6]. While VSMC proteins are crucial in physiology and disease, "vascular smooth muscle cell protein" does not refer to any one druggable target or therapeutic receptor, but rather a heterogeneous group of cell-specific proteins. For structured curation, individual protein names (for example, "smooth muscle actin", "myosin heavy chain 11") should be used rather than the general cellular category. Key details: - “Vascular smooth muscle cell protein” refers to a category, not a canonical, singular molecule or receptor[1][3][4][6]. - Typical marker proteins include smooth muscle actin (ACTA2), myosin heavy chain 11 (MYH11), and SM22α[3][4]. - These proteins mediate contractility, signal transduction, cell adhesion, differentiation, and vascular structural integrity[1][3][4][6]. - VSMC protein expression changes in disease, contributing to cardiovascular pathologies such as atherosclerosis, restenosis, and aneurysm[1][3][5][6]. - Specific drug interactions, mechanisms of action, and safety concerns cannot be assigned to the generic category of "VSMC protein". This entry is not a valid individual therapeutic target but rather a collection of proteins expressed by a cell type. For structured data, specific, individual proteins should be curated instead. Explanation for is_incorrect: "Vascular smooth muscle cell proteins" is not a single, well-defined molecular target, but a non-specific class/description for many proteins expressed by vascular smooth muscle cells and is therefore not suitable for precise, structured target curation.

Other names

VSMC proteinvascular SMC protein