Vascular tone and anti-thrombotic targets

Vascular tone and anti-thrombotic targets represent a broad functional category of molecular entities involved in the regulation of blood flow and the prevention of blood clot formation (StatPearls, 2023, NBK537215). This group includes a wide array of receptors, enzymes, and signaling molecules such as the angiotensin II receptor, nitric oxide synthase, and various clotting factors like Factor Xa and Thrombin (PubMed, 2012, PMID: 22309105). These targets are central to the treatment of cardiovascular conditions, including hypertension, coronary artery disease, and venous thromboembolism (NIH, 2022). Pharmacological intervention in these pathways aims to either modulate the contractile state of vascular smooth muscle or interfere with the enzymatic steps of the coagulation and platelet activation processes (Journal of Clinical Investigation, 2019). Given that this term encompasses multiple distinct biological systems and protein families, it is considered a therapeutic area or physiological grouping rather than a single, specific therapeutic target (IUPHAR/BPS Guide to Pharmacology, 2024).

Other names

Vascular regulatory proteinsHemostatic and vasomotor targetsCardiovascular therapeutic targets

Modulation of vascular smooth muscle contraction and inhibition of the coagulation cascade or platelet activation.