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Target intelligence / Profile preview
Vasoactive Intestinal Peptide Type II Receptor (VPAC2)
- Target
- VPAC2
- Molecular classification
- G protein-coupled receptor, GPCR, Class B GPCR, Secretin family receptor
01
Overview
VPAC2 is a G protein-coupled receptor that binds vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP). It is involved in smooth muscle relaxation, exocrine/endocrine secretion, water/ion flux, immune modulation, circadian rhythm, and insulin secretion. It has been implicated in diseases such as schizophrenia, autism spectrum disorder, and gastric leiomyoma, and is a potential therapeutic target for type 2 diabetes.
- Other names
- Vasoactive intestinal peptide receptor 2PACAP-R-3VIP-R-2VPAC2R
02
Mechanism of action
Activation of adenylyl cyclase and increased intracellular cyclic AMP (cAMP) levels via Gs protein activation.
03
Biological functions
Smooth muscle relaxationExocrine/endocrine secretionWater/ion flux regulationImmune modulationCircadian rhythm regulationInsulin secretionSignal transduction
04
Disease associations
SchizophreniaAutism Spectrum DisorderGastric LeiomyomaType 2 Diabetes
05
Interacting drugs
Ro 25‑1392
1 more in the full profile.
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