Target intelligence / Profile preview

Vasodilation

Overview

Vasodilation is the widening of blood vessels, which decreases blood pressure and increases blood flow. It is mediated by various receptors and pathways, including the nitric oxide-cGMP pathway and endothelial-derived relaxing factors.

Other names: Vasodilatationvascular relaxation

Mechanism of action

Increasing cGMP or cAMP levels, inhibiting calcium entry into smooth muscle cells, activating potassium channels.

Biological functions

Signal transductionvascular tone regulationblood pressure control

Disease associations

Cardiovascular diseasehypertensionatherosclerosis

Safety considerations

Hypotensionreflex tachycardia

Interacting drugs

Nitroglycerin

2 more in the full profile.

Biomarkers

Blood pressurevascular resistance

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