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Vasodilation via nitric oxide pathway
- Molecular classification
- Signaling pathway
01
Overview
The "vasodilation via nitric oxide pathway" describes how endothelial-derived NO acts through sGC/cGMP signaling within vascular smooth muscle cells to induce vessel relaxation—a fundamental mechanism for controlling circulatory dynamics across organ systems.
02
Mechanism of action
Enhance cGMP levels for therapeutic vasodilation
03
Biological functions
Vascular relaxationRegulation of blood pressureRegulation of blood flowInhibition of platelet aggregationReduction of leukocyte adhesionSuppression of vascular smooth muscle cell proliferation
04
Disease associations
HypertensionAtherosclerosisCardiovascular disease
05
Safety considerations
Reduced bioavailability of NO under pathological conditions due to oxidative stress or impaired eNOS function
06
Interacting drugs
Nitrates
1 more in the full profile.
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