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Target intelligence / Profile preview
Vasopressin 1B Receptor (V1BR)
- Target
- V1BR
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Vasopressin/oxytocin family receptor
01
Overview
The Vasopressin 1B Receptor (V1BR) is a Class A G protein-coupled receptor that belongs to the vasopressin/oxytocin family. It is primarily activated by arginine vasopressin and plays a crucial role in regulating ACTH and beta-endorphin release in the anterior pituitary, as well as modulating water, glucose, and salt homeostasis. V1BR is also implicated in social behavior, particularly aggression and social recognition. Selective antagonists are being investigated for potential psychiatric applications.
- Other names
- VPR3AVPR1BAntidiuretic hormone receptor 1BVasopressin V3 receptor
02
Mechanism of action
G protein activation, phosphatidylinositol hydrolysis, calcium mobilization
03
Biological functions
Signal transductionRegulation of ACTH releaseRegulation of beta-endorphin releaseWater balance regulationGlucose metabolism regulationSalt homeostasis regulationModulation of social behaviorCalcium mobilizationPhosphatidylinositol-calcium second messenger system activation
04
Disease associations
Psychiatric disordersStress-related disorders
05
Interacting drugs
Arginine vasopressin
1 more in the full profile.
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