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Target intelligence / Profile preview
Vasopressin Receptor V1A (V1A)
- Target
- V1A
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The vasopressin receptor V1A (AVPR1A) is a G protein-coupled receptor that binds arginine vasopressin. It mediates vasoconstriction, modulates social behaviors, and is involved in platelet aggregation. It is a therapeutic target for conditions involving abnormal social behavior, stress responses, and cardiovascular diseases.
- Other names
- Vasopressin receptor 1AAVPR V1aAntidiuretic hormone receptor 1aSCCL vasopressin subtype 1a receptorVascular/hepatic-type arginine vasopressin receptorAVPR1AArginine Vasopressin Receptor Type 1aAVPRVIAAntidiuretic Hormone Receptor IASCCL subtype
02
Mechanism of action
Antagonism of V1A receptor to reduce vasoconstriction or modulate social behavior.
03
Biological functions
Signal transductionVasoconstrictionModulation of social behaviorPlatelet aggregationGlycogenolysisRegulation of blood pressureStress responseSocial recognition
04
Disease associations
Cardiovascular diseaseSocial behavior disordersStress-related disordersThrombosis
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