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Target intelligence / Profile preview
Vasopressin V1 receptor (V1R)
- Target
- V1R
- Molecular classification
- G protein-coupled receptor
01
Overview
The vasopressin V1 receptor (V1R) is a G-protein coupled receptor that mediates the effects of arginine vasopressin (AVP) on various tissues, including vascular smooth muscle, liver, and brain. Its activation leads to vasoconstriction, increased blood pressure, and modulation of baroreflex sensitivity. It is a key target for vasopressin analogs used in the treatment of hypotensive states like septic or hemorrhagic shock.
- Other names
- V1a vasopressin receptorAVPR1AAntidiuretic hormone receptor 1AVascular/hepatic-type arginine vasopressin receptor
02
Mechanism of action
Agonists activate the receptor, increasing intracellular Ca²⁺ via the phosphatidylinositol-bisphosphate cascade. Antagonists block vasopressin binding and downstream signaling.
03
Biological functions
VasoconstrictionBlood pressure regulationBaroreflex sensitivity modulationPlatelet aggregationHepatic glycogenolysisMyocardial hypertrophyUterine contraction
04
Disease associations
Cardiovascular diseaseHypotensionShockThrombosis
05
Safety considerations
Excessive vasoconstrictionThrombotic riskMyocardial ischemia
06
Interacting drugs
Vasopressin analogs
1 more in the full profile.
07
Biomarkers
AVP levelsGenetic polymorphisms in AVPR1A
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