Arginine vasopressin receptor 1A (AVPR1A or V1A receptor)

Arginine vasopressin receptor 1A (AVPR1A, V1A receptor) is a G protein-coupled receptor found predominantly in vascular smooth muscle, platelets, liver, myometrium, and brain. Its principal endogenous ligand is vasopressin (antidiuretic hormone). The receptor mediates vasopressor (vasoconstrictor) effects via activation of phosphatidyl-inositol-calcium signaling through Gq proteins, resulting in increased intracellular calcium and smooth muscle contraction. AVPR1A is also involved in platelet aggregation, regulation of arterial blood pressure, uterine contraction, and various social and behavioral processes. Clinically, V1A receptor ligands are important in cardiovascular management (e.g., vasopressin and terlipressin for shock) and are explored in the context of neuropsychiatric and social behavior-related research. Overactivity can cause hypertension and thrombosis, while genetic polymorphisms in the gene are linked to variability in social behavior and mating in humans.

Other names

Vasopressin V1a receptorV1-vascular vasopressin receptorAntidiuretic hormone receptor 1AAVPR1Vascular/hepatic-type arginine vasopressin receptor

Agonists stimulate vasoconstriction via Gq-protein activation. Antagonists block receptor-mediated vasoconstriction and related effects. Indirect effects on blood pressure, platelet aggregation, and uterine contraction.