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Vasopressin V1b Receptor (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The vasopressin V1b receptor (V1bR), also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B, is a G protein-coupled receptor (GPCR) primarily expressed in the anterior pituitary gland. It is activated by arginine vasopressin (AVP) and plays a key role in regulating ACTH release and the HPA axis. Due to its role in stress responses, it is being explored as a therapeutic target for stress, anxiety, depression, and metabolic syndrome.
- Other names
- Vasopressin 3 ReceptorVPR3Antidiuretic Hormone Receptor 1BAVPR3Vasopressin V3 Receptor
02
Mechanism of action
Gq protein activation, phospholipase C stimulation, increased intracellular calcium
03
Biological functions
Signal transductionRegulation of ACTH releaseHPA axis regulationRegulation of glucose metabolismModulation of social behaviorsCircadian rhythm adaptation
04
Disease associations
Stress-related disordersAnxietyDepressionMetabolic syndromeBehavioral conditions
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