VEGFRs, PDGFRs, FGFRs, Src-family kinases, FLT3, Lck (N/A)

These proteins comprise several major families of receptor tyrosine kinases (VEGFR, PDGFR, FGFR, FLT3) and non-receptor tyrosine kinases (Src-family, Lck). They regulate critical cellular processes including proliferation, differentiation, angiogenesis, and immune cell signaling. Aberrant activity, mutation, or overexpression of these kinases is implicated in a wide spectrum of human diseases, most notably cancer (e.g., acute myeloid leukemia for FLT3, breast cancer for VEGFR and PDGFR, and solid and hematological tumors for FGFR and Src-family kinases). They are important targets for several approved drugs, but therapeutic challenges include off-target effects, resistance, and biomarker selection for effective therapy. The query incorrectly combines these distinct proteins/families, as there is no single molecule or receptor with this combined name.

Other names

VEGF receptorPDGF receptorFGF receptorc-SrcFynLynYesLckCD135Fms-like tyrosine kinase 3Lymphocyte-specific protein tyrosine kinase

Inhibition of kinase activity (by small molecule or antibody); Blockade of ligand binding or receptor dimerization; Downregulation of malignant signaling pathways