Venezuelan equine encephalitis virus envelope glycoprotein E2 (E2)

The Venezuelan equine encephalitis virus envelope glycoprotein E2 is a structural component of the viral envelope, forming heterodimers with E1 that assemble into trimeric spikes on the virion surface. Derived from cleavage of the pE2 precursor (which includes E3), E2 mediates host receptor binding for viral entry, including interactions with LDLRAD3, heparan sulfate, and other receptors, and interacts with the capsid protein during assembly and maturation. It features domains A (receptor binding), B (protects E1 fusion loop), C (host recognition), and a β-ribbon connector, with its C-terminal tail anchoring to the viral membrane and binding capsid.

Other names

pE2 (precursor form)E2 glycoprotein

Inhibits viral attachment to host cells; Blocks viral egress; Prevents viral fusion; Competes for receptor binding (e.g., LDLRAD3)