VENT homeobox pseudogene 2 (VENTXP2)

VENTXP2 is a member of the VENT homeobox gene family and is classified as a pseudogene, meaning it is a non-functional genomic sequence derived from a once-protein-coding gene. Pseudogenes generally result from duplication or retrotransposition events and typically lack necessary regulatory sequences or accumulate disabling mutations such as frameshifts or premature stop codons. VENTXP2 does not produce a functional protein and, unlike its functional family member VENTX, does not act as a transcription factor, nor is it involved in development or disease. The confusion may arise from the similarity to VENTX, which is a functional homeobox gene implicated in hematopoiesis and leukemia, but VENTXP2 itself lacks any known biological function, role in disease, or therapeutic relevance. VENTXP2’s gene locus is located on chromosome 13q31.1. Note: If a functional VENTX homeobox gene target is intended, you should refer to “VENTX” and not “VENTXP2”; “VENTXP2” refers only to the pseudogene sequence and is not a drug/protein target.

Other names

VENT homeobox pseudogene 2VENTXP2VENTX2P2Ensembl: ENSG00000215037NCBI Gene: 100287345HGNC: 30901

None