VENT homeobox pseudogene 7 (VENTXP7)

VENT homeobox pseudogene 7 (VENTXP7, HPX42, VENTX1) is a retrotransposed pseudogene belonging to the Ventx-family of homeobox genes, located at chromosomal locus 3p24.3[5]. While homeobox genes typically encode DNA-binding transcription factors important in embryonic development, VENTXP7 lacks protein-coding potential due to premature mutations and/or rearrangements and is not believed to produce functional protein product[5]. Historical annotations incorrectly listed it as VENTX1 or as a functional gene, but subsequent genomic and phylogenetic analysis clarified that VENTXP7 is a pseudogene derived from the functional VENTX gene and shares significant sequence identity (86%) with VENTX after removal of certain repetitive elements[5]. No disease associations or drug interactions have been reported, and it is not part of any recognized signaling, disease, or developmental network in humans[3][5][6].\n\nVENTXP7 is relevant only for annotation and evolutionary studies of the homeobox gene superfamily and is not a bona fide therapeutic or research target[5].\n\nNotes: \n- This entry is not a receptor, enzyme, transporter, or functional protein, and thus is not a \"target\" as used in drug discovery or molecular biology contexts[3][5][6]. \n- The name VENTX1 is obsolete/misapplied; the correct designation is VENTXP7[5]. \n- The only functional human Ventx-family gene is VENTX[5]. \n- siRNA and shRNA design resources may list VENTXP7, but these are not recommended for experimental use, as indicated by suppliers and design algorithm rejections[7].\n\nSummary: \nVENT homeobox pseudogene 7 (VENTXP7, HPX42) is a retrotransposed non-coding pseudogene and does not act as a functional gene, disease gene, receptor, or molecular target in humans[3][5][6][7].

Other names

HPX42VENTX1