Ventricular zone-expressed PH domain-containing protein homolog 1 (VEPH1)

Ventricular zone-expressed PH domain-containing protein homolog 1 (VEPH1) is a cytoplasmic adaptor protein characterized by a pleckstrin homology (PH) domain that enables interactions with phosphoinositides and various protein partners[2][4]. VEPH1 interacts with transforming growth factor-beta receptor type 1 (TGFBR1), inhibiting the dissociation and nuclear accumulation of SMAD2, and thereby impairs TGF-β signaling[2][5]. It can also modulate other signaling pathways, including FOXO, Hippo, and Wnt, highlighting a broader regulatory role in signal transduction[2][3]. In cancer, particularly ovarian cancer, VEPH1 expression suppresses tumor vascularization and slows tumor growth by inhibiting AKT pathway activation and reducing VEGFA and IL8 expression[1]. VEPH1 is not a typical target for drug therapy and is not currently considered a direct therapeutic target, but acts as a key modulator within signaling networks relevant to tumor biology and possibly other diseases such as hypotrichosis[1][5].

Other names

VEPH1KIAA1692MELTprotein meltedFLJ12604