Vesicle amine transport 1 like (VAT1L)

VAT1L (Vesicle amine transport 1 like) is a protein encoded in humans by the *VAT1L* gene, related to VAT1 and highly conserved across vertebrates. VAT1L is predicted and partly validated to have oxidoreductase activity within the NADPH-dependent quinone oxidoreductase family, and functions as an integral membrane protein in cholinergic synaptic vesicles, possibly regulating vesicle transport. It may also modulate mitochondrial fusion and participate in phospholipid transfer between the endoplasmic reticulum and mitochondria. Limited experimental evidence suggests roles in cell migration and cancer cell motility, indicating VAT1L as a potential but unvalidated anticancer drug target; a naturally occurring product (neocarzilin A) inhibits VAT1-regulated cell motility. VAT1L is a paralog of VAT1 and is expressed in multiple tissues, particularly in nervous system structures. There is no direct evidence of VAT1L serving as a receptor, ion channel, transporter, or being involved in signal transduction, and its molecular mechanism and authentic substrates remain only partly characterized.

Other names

Synaptic vesicle membrane protein VAT-1 homolog-likeVAT1LKIAA1576Vesicle amine transport protein 1 homolog (T. californica)-likeVesicle amine transport protein 1 homolog-like (T. californica)Vesicle amine transport 1-like

Inhibiting VAT-1-related pathways reduces cancer cell motility (in vitro), potentially by modulating redox and vesicular processes in cancer cells