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Target intelligence / Profile preview
Synaptobrevin
- Molecular classification
- Vesicle-associated membrane proteins (VAMP), v-SNARES, SNARE protein
01
Overview
Synaptobrevin is a small integral membrane protein found in secretory vesicles, belonging to the VAMP family. It is a v-SNARE that plays a central role in vesicle fusion during exocytosis, particularly in neurons for neurotransmitter release. It forms part of the core SNARE complex with syntaxin and SNAP-25, driving membrane fusion events.
- Other names
- VAMPv-SNAREsybn-sybVesicle-associated membrane protein
02
Mechanism of action
Cleavage of synaptobrevin, inhibiting vesicle fusion
03
Biological functions
Vesicle fusionExocytosisNeurotransmitter releaseIntracellular trafficking
04
Disease associations
Neurodegenerative diseaseNeurological disorders
05
Safety considerations
Potential for broad impact on cellular secretion pathways if targeted systemicallyHigh degree of conservation across eukaryotes suggests potential for off-target effects
06
Interacting drugs
Botulinum toxin
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