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Vesicle-associated membrane protein 1 (None)
- Target
- None
- Molecular classification
- Synaptobrevin, Vesicle-associated membrane proteins, SNAREs
01
Overview
Vesicle-associated membrane protein 1 (VAMP1) is a SNARE protein essential for vesicle fusion, particularly in neurotransmitter release. Alternative splicing creates isoforms with different subcellular localizations, including VAMP-1A at synapses and VAMP-1B at mitochondria. It plays a key role in SNARE complex formation with syntaxins and SNAP25. Mutations are linked to congenital myasthenic syndrome, while expression levels may correlate with survival in certain cancers.
- Other names
- SPAX1SYB1CMS25vesicle associated membrane protein 1
02
Mechanism of action
Mediates docking and fusion between synaptic vesicles and presynaptic membranes
03
Biological functions
SNAP receptor activitySyntaxin binding activitySNARE complex assemblyRegulation of synaptic vesicle exocytosis/fusion events
04
Disease associations
Congenital myasthenic syndromeLung cancer
05
Biomarkers
VAMP1 expression levels (prognostic in lung cancer)
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