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Vesicle-associated Membrane Protein 2 (VAMP2)

Target: VAMP2
Molecular classification: VAMP/synaptobrevin family, SNARE protein

Overview

Vesicle-associated membrane protein 2 (VAMP2), also known as synaptobrevin-2, is a key SNARE protein that mediates vesicle fusion events, particularly in neurons. It is essential for neurotransmitter release and plays roles in hormone secretion and GPCR trafficking. Mutations in VAMP2 are linked to neurodevelopmental disorders.

Other names: Synaptobrevin-2

Biological functions

Vesicle fusionNeurotransmitter releaseHormone secretionGPCR trafficking

Disease associations

Neurodevelopmental disordersAutism spectrum disorder

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