Target intelligence / Profile preview

Vesicle-associated Membrane Protein 2 (VAMP2)

Target
VAMP2
Molecular classification
VAMP/synaptobrevin family, SNARE protein
01

Overview

Vesicle-associated membrane protein 2 (VAMP2), also known as synaptobrevin-2, is a key SNARE protein that mediates vesicle fusion events, particularly in neurons. It is essential for neurotransmitter release and plays roles in hormone secretion and GPCR trafficking. Mutations in VAMP2 are linked to neurodevelopmental disorders.

Other names
Synaptobrevin-2
02

Biological functions

Vesicle fusionNeurotransmitter releaseHormone secretionGPCR trafficking
03

Disease associations

Neurodevelopmental disordersAutism spectrum disorder

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