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Vesicle-associated membrane protein 5 (VAMP5)
- Target
- VAMP5
- Molecular classification
- SNARE protein, Vesicle-associated membrane protein (VAMP)/synaptobrevin family, Membrane trafficking protein
01
Overview
Vesicle-associated membrane protein 5 (VAMP5) is a member of the SNARE superfamily, specifically the VAMP/synaptobrevin protein family, which is essential for vesicular fusion and membrane trafficking[1][2][3][4][5]. VAMP5 is predominantly expressed in skeletal muscle and heart, with key roles in vesicle trafficking during myogenesis and in phagosome formation within macrophages, interacting with other SNAREs such as SNAP23[2][3][5]. Genetic studies have implicated VAMP5 variants as risk factors for Hirschsprung disease, reflecting its importance in vesicle transport for neural crest cell function[1]. VAMP5 has also been studied for potential contributions to tumor progression and investigated as a candidate in other diseases, though direct therapeutic targeting and interacting drugs have not been established[4][1].
- Other names
- VAMP5MyobrevinHSPC191VAMP-5vesicle-associated membrane protein 5
02
Biological functions
Vesicle-mediated transportVesicular fusion and exocytosisMembrane trafficking in myogenesisPhagosome formation (immune response)Golgi to plasma membrane protein transport
03
Disease associations
Hirschsprung disease (HSCR) (polymorphisms associated with disease risk)Cancer (implicated in tumor progression, especially via vesicle transport)Potential, but unconfirmed role in primary open-angle glaucoma
04
Biomarkers
VAMP5 variants (e.g., SNPs) as genetic risk markers for Hirschsprung disease
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