Vesicle-associated membrane protein 7 mRNA (VAMP7 mRNA)

Vesicle-associated membrane protein 7 (VAMP7) mRNA is the genetic template for the VAMP7 protein, a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family (Source: UniProt P51809). The encoded protein, also known as tetanus-insensitive VAMP (TI-VAMP), is a v-SNARE that mediates the fusion of late endosomes and lysosomes with the plasma membrane, as well as autophagosome-lysosome fusion (Source: Wikipedia). VAMP7 is critical for diverse cellular processes, including neurite outgrowth, cell migration, and the release of cytotoxic granules from natural killer cells and T-lymphocytes (Source: NIH, PMID: 18078657). In disease, VAMP7 mRNA is frequently overexpressed in various malignancies, such as breast and gastric cancers, where it facilitates tumor invasion and exosome secretion (Source: GeneCards). It is also implicated in obesity, where its inhibition can trigger apoptosis in preadipocytes by disrupting autophagic flux (Source: Frontiers in Pharmacology). Therapeutic approaches targeting VAMP7 mRNA, such as siRNA-mediated knockdown, are being explored to prevent transplant rejection and treat cancer, while small molecules like Celastrol have been shown to directly bind and inhibit the functional protein (Source: NIH, Frontiers in Pharmacology).

Other names

SYBL1 mRNATI-VAMP mRNATetanus-insensitive VAMP mRNASynaptobrevin-like protein 1 mRNA

RNA interference, Antisense inhibition, Direct protein binding