Vesicle-trafficking protein SEC22a (SEC22A)

Vesicle-trafficking protein SEC22a (SEC22A) is a SNARE protein that facilitates the transport of vesicles between the ER and Golgi, an essential process for protein sorting, secretion, and cellular homeostasis[1][2][4][5]. SEC22A forms part of the multiprotein SNARE complex, promoting membrane fusion events both in the secretory pathway and in autophagic processes[1]. Its functions ensure the correct trafficking and localization of newly synthesized proteins within the cell. Mutations or dysfunctions in SEC22A or its homologs can result in diseases such as neurodegeneration (e.g., Alzheimer's disease), Warburg Micro syndrome, and atherosclerosis, largely due to impaired protein and lipid transport mechanisms[1][5]. Although critical for cell physiology, SEC22A is not a direct pharmacological target but may be of interest in studies of membrane trafficking, cell biology, and certain rare genetic disorders.

Other names

SEC22ASEC22 homolog ASEC22L2SEC22 vesicle-trafficking protein homolog ASEC22 vesicle-trafficking protein-like 2