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Target intelligence / Profile preview
Vesicle-trafficking protein SEC22b (SEC22B)
- Target
- SEC22B
- Molecular classification
- SNARE protein, Vesicle-trafficking protein, R-SNARE, ER-resident protein, Tail-anchored protein
01
Overview
Vesicle-trafficking protein SEC22b (SEC22B) is an endoplasmic reticulum (ER)-resident SNARE protein that mediates membrane fusion events crucial for protein trafficking between the ER and Golgi apparatus. It associates with syntaxins and other SNARE proteins to form complexes that drive anterograde (ER to Golgi) and retrograde (Golgi to ER) vesicle transport, playing critical roles in secretion, antigen cross-presentation, secretory autophagy, and membrane expansion. SEC22B is required for platelet alpha-granule biogenesis and for the morphology of certain endothelial organelles, and its dysfunction has been implicated in neurodegeneration (Alzheimer’s disease), cancer progression, and infectious disease pathogenesis[1][2][3][4][5].
- Other names
- SEC22BSEC22L1ERS-24ERS24ER-Golgi SNARE of 24 kDaSEC22 vesicle-trafficking protein homolog BSEC22 vesicle-trafficking protein-like 1
02
Biological functions
ER-Golgi protein traffickingVesicle fusionPlatelet alpha-granule biogenesisEndothelial Weibel-Palade body formationMembrane expansionAntigen cross-presentationSecretory autophagyIntracellular lipid transferER–plasma membrane contacts
03
Disease associations
Cancer (liver, colorectal)Neurodegenerative disease (e.g., Alzheimer's disease)AtherosclerosisInfection (Legionellosis, Pontiac Fever)Platelet disorders
04
Safety considerations
No specific safety concerns reported; genetic mutations may be related to developmental lethality or disease pathogenesis
05
Biomarkers
SEC22B has been considered among panels of proteins for Alzheimer’s disease biomarker studies but is not validated as a clinical biomarker
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