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Target intelligence / Profile preview
Vesicular Acetylcholine Transporter (VAChT)
- Target
- VAChT
- Molecular classification
- Transporter, Solute Carrier Family 18
01
Overview
The Vesicular Acetylcholine Transporter (VAChT/SLC18A3) is a critical presynaptic membrane protein responsible for loading acetylcholine into secretory vesicles through a proton-coupled antiport mechanism. Its function underpins fast cholinergic neurotransmission throughout both central and peripheral nervous systems. Genetic disruption results in severe developmental defects or lethality, underscoring its essential role. Its unique structure-function relationship makes it an important target both pharmacologically—for modulating cholinergic tone—and diagnostically—as an imaging biomarker reflecting neuronal health.
- Other names
- SLC18A3Solute carrier family 18 member A3CMS21VACHT[1]
02
Mechanism of action
Proton-coupled antiport of acetylcholine into synaptic vesicles
03
Biological functions
Neurotransmitter transportVesicular transportAcetylcholine storage
04
Disease associations
Neurodegenerative diseaseMyasthenic syndromesCognitive deficits
05
Safety considerations
Essential for life; disruption leads to severe developmental defects or lethality
06
Biomarkers
Cholinergic neuron integrity (using PET imaging agents)
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