Target intelligence / Profile preview

Vesicular Monoamine Transporter (VMAT)

Target: VMAT
Molecular classification: Transporter

Overview

The vesicular monoamine transporter (VMAT) is a membrane-embedded transport protein found in the membranes of synaptic vesicles within presynaptic neurons. Its primary function is to transport monoamine neurotransmitters—including dopamine, serotonin, norepinephrine, epinephrine, and histamine—from the cytosol into storage vesicles. This process enables the regulated release of these neurotransmitters into synapses for neuronal communication.

Mechanism of action

Inhibition of vesicular monoamine transport

Biological functions

Neurotransmitter transportNeurotransmitter storageRegulation of neurotransmitter release

Disease associations

HypertensionPsychiatric disordersParkinson's diseaseDrug addiction

Interacting drugs

Tetrabenazine

2 more in the full profile.

Beyond the preview

Go deeper on Vesicular Monoamine Transporter (VMAT).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Vesicular Monoamine Transporter (VMAT).

Explore the full profile