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Target intelligence / Profile preview
Vesicular Monoamine Transporter Type 2 (VMAT2)
- Target
- VMAT2
- Molecular classification
- Transporter, Solute Carrier Family 18
01
Overview
Vesicular Monoamine Transporter Type 2 (VMAT2) is an essential neuronal protein encoded by SLC18A2 that loads key neurotransmitters into synaptic vesicles using a proton-driven mechanism. It plays crucial roles in brain signaling regulation and serves as an important drug target for several neuropsychiatric conditions due to its role controlling availability/release of major biogenic amines.
- Other names
- SLC18A2
02
Mechanism of action
Inhibition of vesicular monoamine uptake leading to decreased neurotransmitter release and increased cytosolic breakdown.
03
Biological functions
Monoamine transportNeurotransmitter storageSynaptic vesicle loading
04
Disease associations
Parkinson’s diseaseSchizophreniaDepressionHuntington’s disease
05
Interacting drugs
Tetrabenazine
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