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Target intelligence / Profile preview
Vesicular Nucleotide Transporter (VNUT)
- Target
- VNUT
- Molecular classification
- Solute Carrier Family 17 (SLC17), Organic Anion Transporter, Transporter
01
Overview
The vesicular nucleotide transporter (VNUT) is a membrane protein (SLC17A9) responsible for the active transport and storage of nucleotides, primarily ATP, into secretory vesicles. Upon stimulation, these vesicles release ATP, enabling purinergic signaling. VNUT plays roles in pain perception, inflammation, and other physiological processes, making it a potential therapeutic target. Inhibitors like clodronate and EPA metabolites can modulate its activity.
- Other names
- SLC17A9
02
Mechanism of action
Inhibition of vesicular nucleotide transport, reducing ATP release and purinergic signaling
03
Biological functions
Nucleotide transportATP storagePurinergic signaling regulationVesicular transport
04
Disease associations
Pain perceptionInflammationMetabolic diseaseFibrosis
05
Interacting drugs
Clodronate
2 more in the full profile.
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