Target intelligence / Profile preview

Vesicular Stomatitis Virus (VSV)

Target
VSV
Molecular classification
Virus, RNA virus, Rhabdoviridae, Vesiculovirus
01

Overview

Vesicular stomatitis virus (VSV) is an enveloped, negative-sense single-stranded RNA virus belonging to the genus *Vesiculovirus* in the family *Rhabdoviridae*. VSV primarily affects livestock but can also infect swine, sheep, goats, llamas, alpacas, wildlife species, and occasionally humans. The disease it causes—vesicular stomatitis—is characterized by blister-like sores on the mouth, snout, teats, and feet of affected animals. The virus uses the G protein to attach to LDL receptor family members on host cells and the M protein plays a role in immune evasion by suppressing type I interferon responses. Transmission occurs mainly via biting insects. Disinfection can be achieved via several methods.

02

Mechanism of action

Disinfection

03

Biological functions

Viral replicationInfectionImmune evasion
04

Disease associations

Vesicular stomatitisInfection
05

Safety considerations

Zoonotic potentialDifferential diagnosis with other vesicular diseases (e.g., foot-and-mouth disease)
06

Interacting drugs

Chlorine dioxide

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