Vessel lumen of tumor-feeding and hypervascular arteries

The vessel lumen of tumor-feeding and other hypervascular arteries represents an anatomical and physiological site rather than a specific molecular target like a receptor or enzyme. These vessels are the primary conduits for blood, oxygen, and nutrients to malignant growths, often characterized by abnormal architecture, high flow rates, and increased permeability (National Cancer Institute, https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tumor-feeding-artery). In interventional oncology, these arteries are the primary targets for procedures such as Transarterial Chemoembolization (TACE) and Transarterial Radioembolization (TARE), where embolic agents and drugs are delivered directly into the lumen to induce tumor ischemia and necrosis (StatPearls, https://www.ncbi.nlm.nih.gov/books/NBK537189/). Additionally, certain therapeutic classes like vascular disrupting agents (VDAs) specifically target the existing endothelial structure of these vessels to trigger rapid vascular collapse and subsequent tumor death (PubMed, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824893/). While not a protein or gene, the selective targeting of these hypervascular structures is a cornerstone of localized cancer therapy for hypervascular tumors like hepatocellular carcinoma (PubMed, https://pubmed.ncbi.nlm.nih.gov/33454305/).

Other names

Tumor-feeding arteriesHypervascular tumor vesselsTumor vasculatureFeeding vesselsTumor-feeding vessel lumen

Induction of tumor ischemia and necrosis through mechanical occlusion of blood supply (embolization) and localized delivery of chemotherapeutic agents (StatPearls, https://www.ncbi.nlm.nih.gov/books/NBK537189/).