Vexin (VXN)

Vexin is a 207-amino acid nuclear protein enriched in the brain and spinal cord, with a high isolectric point (basic, rich in arginine) and predicted to undergo multiple post-translational modifications (glycation, phosphorylation, acetylation, SUMOylation, and O-glycosylation) that regulate protein function and cell signaling[1]. Vexin plays a key role in neuron differentiation and neurogenesis, particularly in the developing central nervous system, and has been shown to cooperate with neural bHLH transcription factors and p27 to enhance neurogenesis and promote cell cycle exit[2][7]. Its exact molecular mechanism and structural features remain incompletely characterized, and it is not considered a therapeutic target such as a receptor, enzyme, or ion channel. Vexin's expression is altered in several disease processes, most notably in breast cancer (where it may contribute to endocrine therapy resistance via its ESR1 enhancer region methylation) and various neurological or psychiatric disorders[1][3][7].

Other names

VexinVXNC8orf46MGC33510uncharacterized protein C8orf46