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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Vi Capsular Polysaccharide Antigen (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Vi capsular polysaccharide antigen is a surface-expressed linear polysaccharide unique to Salmonella enterica serovar Typhi, the causative agent of typhoid fever. It is a major virulence factor, enabling S. Typhi to evade innate immune responses by inhibiting phagocytosis and reducing complement deposition. It is also an important target for vaccine development; purified Vi antigen is used as a standalone vaccine with moderate efficacy in adults, while conjugation to carrier proteins converts it into a highly effective vaccine across all age groups.
- Other names
- Vi capsular polysaccharideVi polysaccharideVi antigen
02
Mechanism of action
Antibody-mediated neutralization, complement activation, monocyte phagocytosis
03
Biological functions
Immune evasionInhibition of phagocytosisReduction of complement depositionModulation of proinflammatory signaling
04
Disease associations
Typhoid feverInfection
05
Safety considerations
Limited efficacy of standalone Vi vaccinePoor efficacy in children under two years old for standalone Vi vaccine
06
Interacting drugs
Vi polysaccharide vaccine
1 more in the full profile.
07
Biomarkers
Anti-Vi IgG antibodies
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