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Target intelligence / Profile preview
Vi Capsular Polysaccharide Antigen (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Vi capsular polysaccharide antigen is a surface-exposed, linear homopolymer found in the capsule of *Salmonella enterica* serovar Typhi. It is a key virulence factor, enabling evasion of phagocytosis and modulating immune responses via DC-SIGN interaction. It serves as the basis for subunit vaccines against typhoid fever, eliciting protective serum antibodies.
- Other names
- Vi capsular polysaccharideVi antigen of Salmonella TyphiViCPS
02
Mechanism of action
Vaccination induces anti-Vi antibodies, leading to opsonization and complement-mediated killing of *S. Typhi*.
03
Biological functions
Immune evasionPhagocytosis modulationAdhesionCapsule formationDC-SIGN interactionVirulence factor
04
Disease associations
Typhoid feverInfection
05
Safety considerations
Injection site reactionsLimited efficacy in young children
06
Interacting drugs
Typherix
2 more in the full profile.
07
Biomarkers
Anti-Vi antibody titersIgM anti-Vi antibodiesIgG anti-Vi antibodies
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