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Target intelligence / Profile preview
Vi Capsular Polysaccharide of Salmonella Typhi (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Virulence Factor
01
Overview
The Vi capsular polysaccharide (Vi antigen) is a surface-expressed linear polymer found on *Salmonella enterica* serovar Typhi. It is a major virulence factor that enables the bacterium to evade host immune responses and establish infection. It confers resistance to phagocytosis and complement-mediated killing, and suppresses inflammatory responses. Purified Vi polysaccharide forms the basis for licensed vaccines against typhoid fever.
- Other names
- Vi polysaccharideVi capsule
02
Mechanism of action
N/A
03
Biological functions
Immune evasionComplement resistanceSuppression of inflammatory responsesInhibition of neutrophil chemotaxisVaccine antigen
04
Disease associations
Typhoid feverInfection
05
Biomarkers
Presence of Vi antigen in Salmonella Typhi (diagnostic marker)Antibody response to Vi antigen (vaccine efficacy)
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