Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Vibrio cholerae (live attenuated) (V. cholerae (live attenuated))
- Target
- V. cholerae (live attenuated)
- Molecular classification
- Bacterium, Vaccine Strain
01
Overview
Live attenuated Vibrio cholerae strains are genetically modified or naturally less virulent forms used as oral vaccines against cholera. These strains typically have deletions or mutations in key virulence genes such as ctxA/B (cholera toxin) or flagellin genes to reduce reactogenicity while retaining immunogenicity. Vaccination with live attenuated V. cholerae induces robust humoral responses, including high titers of vibriocidal antibodies. It serves both as a direct target for vaccination against classical epidemic/pandemic *Vibrio* infections and as a platform/carrier system for expressing foreign antigens from other pathogens.
- Other names
- Live attenuated Vibrio choleraeV. cholerae CVD 103-HgRAttenuated V. choleraeCholera vaccine (live attenuated)
02
Mechanism of action
Induction of vibriocidal antibodies and mucosal immunity through attenuated colonization of the intestine.
03
Biological functions
AntigenImmune stimulationColonization of intestinal mucosa (attenuated)Induction of humoral immunity
04
Disease associations
Prevention of CholeraVaccine vector for other pathogens (potential)
05
Safety considerations
Potential for reversion to virulence (low probability in well-characterized strains)Contraindicated in immunocompromised individualsPotential for interference with other oral vaccines
06
Biomarkers
Vibriocidal antibody titersLPS-specific antibody levelsCholera toxin-specific antibody levelsPlasmablast response (early marker)
Beyond the preview
Go deeper on Vibrio cholerae (live attenuated) (V. cholerae (live attenuated)).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Vibrio cholerae (live attenuated) (V. cholerae (live attenuated)).